Abstract: Objective: To investigate the leakage of venous transfusion and its influencing factors in a tertiary hospital.Methods: The leakage of venous transfusion in 1 680 patients from ENT in a top tertiary hospital was investigated from Jan 2012 to Jan 2013,the influencing factors of which was analyzed.Results: Among 1 453 patients treated with venous transfusion,49 cases fluid exudation from 38 patients were found,the fluid exudation rate,annual incidence and incidence density were 2.62%,3.37% and 1.29,respectively.The differences of the leakage of venous transfusion rate in different gender,age,infusion device,length of service,the first infusion and caregiver on the day were statistically significant(P<0.05 to P<0.01).The male patients,children and older people,no caregiver on the day and lower length of service were the risk factors of leakage of venous transfusion(P<0.05 to P<0.01).Conclusions: The male patients,children and the elderly patients need to strengthen patrol during the venous transfusion,primary nurse should inform the importance of the hospital care for patients.Improving the intravenous infusion skill of lower length of service nurse,and strict observating the puncture local skin can reduce the incidence of venous leakage.