Abstract: Objective: To observe the clinical effects of salvianolate in the treatment of the elderly patients with coronary artery disease complicated with heart failure.Methods: Seventy-two elderly patients with coronary artery disease complicated with heart failure were randomly divided into the control group and salvianolate group using number table method(36 cases each group).The control group were treated with conventional method,the salvianolate group were treated with salvianolate by intravenous injection based on conventional method for 14 days.The ejection fraction(EF),stroke volume(SV),N-terminal type B natriuretic peptide(Nt-proBNP) level and HF Lee score in two groups were measured before and after treatment,the clinical effects between two groups were evaluated according to the HF Lee score.Results: Compared before treatment,the EF and SV in two groups increased significantly after treatment(P< 0.01),and the increasing degrees of EF and SV in salvianolate group were significantly higher than those in control group(P< 0.01).Compared before treatment,the Nt-proBNP level and HF Lee score in two groups decreased significantly after treatment(P< 0.01),and the Nt-proBNP level and HF Lee score in salvianolate group were significantly better than those in control group(P< 0.05).The effective rates in control group and salvianolate group were 47.22% and 75.00%,respectively,the difference of which was statistically significant(P< 0.01).Conclusions: The treatment of coronary artery disease complicated with heart failure in the elderly patients with salvianolate based on the conventional therapy can significantly improve the cardiac function of patients,which has good clinical effects,and is worth promoting.