Abstract: Objective: To examine the relationship between hyperhomocysteinemia,cerebrovascular disease and the relative factors.Methods: The four groups randomly selected had no obvious differences in age and sex.The plasma homocysteine(Hcy) levels of 60 patients with cerebral infarction,30 patients with cerebral hemorrhage,30 patients with other neurological diseases and 30 normal controls were measured by STE.Besides Hcy,each patient received laboratory examinations including folate and Vitamin B₁₂.Results: The plasma Hcy level in the group with cerebral infarction or cerebral hemorrhage was significantly higher than that with other neurological diseases or normal controls(P<0.01).Correlation analysis showed that plasma Hcy in stroke was negatively correlated with plasma folate and Vitamin B₁₂ (P<0.05).Conclusions: There is a certain relationship between the level of Hcy and cerebrovascular disease;therefore folate and Vitamin B₁₂ supplementation might help to lower the risk factors.