Abstract: Objective:To investigate the value of detecting microalbumin(mALB) and n-acetyl-β-D-glucosaminidase(NAG) in diagnosis of early renal damage in patients with hypertension.Methods:Mimmunoprecipitation in liquid phase was used to measure the urinary mALB,and the rate method was employed to determine the urinary NAG activity of 78 patients with hypertension,apply agarose gel electrophoresis detect vrine NAG activated.Results:The mALB in 43 cases(55.13%) increased,which was significantly higher than that of conventionl urine protein positive rate of 12.82(P<0.01).The urinary NAG and urinary mALB in the patients with hypertension were significantly higher than those of the control(P<0.01),and tended to rise with the duration of the disease.Conclusions:Urinary mALB and urinary NAG may help to predict the hypertensive renal damage in the early stage.