乙型肝炎病毒前S1抗原与HBV血清标志物之间的相关性探讨

The relativity between Pre-S1 antigen and hepatitis B virus serum markers

摘要: 目的: 探讨乙型肝炎病毒前S1抗原与HBV血清标志物(即"乙肝五项")之间的相关性。方法: 用EL ISA法检测457例HBsAg(+)血清,分析其"乙肝五项"与前S1抗原之间的关系。结果: 前S1抗原与"乙肝五项"有不同的相关性,其具有独立的检测价值。结论: 前S1抗原作为HBV感染、复制的指标较HBeAg更敏感,与乙型肝炎的活动性有关,对"乙肝五项"检测有重要的补充作用。

Abstract: Objective: To investigate the relativity between Pre-S1 antigen and hepatitis B virus serum markers(HBV M).Methods: Four hundred and fifty-seven HBsAg positive serums were inspected by ELISA and the relationship between HBV-M and Pre-S1 antigen were analyzed.Results: Pre-S1 antigen and HBV-M had different relativity and independent inspection value.Conclusions: As the index of infection and reproduction of HBV,Pre-S1 antigen is much more sensitive than HBeAg.Pre-S1 antigen is related to the activity of HBV and has the supplemental function to HBV-M inspection.