Abstract: Objective: To investigate the common complications in plasmapheresis for treatment of severe hepatitis. Methods: The clinical data of 58 cases of severe hepatitis complication treated by plasmapheresis were analyzed retrospectively. Results: All the 58 cases were performed the therapy for 202 times. The incidence of complication was 54.5%,among which,the numbness of the face and head accounted for 22.8%,skin itching 17.3% and decline of blood pressure 5.9%. Conclusions: Complications are quite common in the performance of plasmapheresis but usually slight,which can be alleviated after proper treatment.