Abstract: Objective:To observe the analgesic and sedative effects of sufentanil and remifentanil during and after pediatric tonsillectomy and adenoidectomy surgery.Methods:One hundred patients involved in selective operation were chosen and divided into two groups randomly:sufentanil group (S group,n=50) and remifentanil group (R group,n=50).Patients in S group were rapidly induced by 0.2 μg/kg sufentanil,and were maintained with 0.2 μg·kg^-1·h^-1 in the operation.Sufentanil was withdrawn 30 min before the operation completed.Patients in R group were rapidly induced by 2 μg/kg remifentanil,and were maintained with 6 μg·kg^-1·h^-1 in the operation.Remifentanil was withdrawn 5 min before the operation completed.The hemodynamic indexes during and after the operation as well as the postoperative sedative degree of patients in the two groups were respectively observed.Results:No significant difference of hemodynamic indexes during the operation was observed between the two groups (P>0.05).No obvious difference was shown between the mean arterial pressure 5 min after removing tube in S group and the basic values;and a statistical difference was shown in R group (P<0.01).The Ramsay score of children in S group after operation was more appropriate,and VAS score was lower.Conclusions:Both sufentanil and remifentanil drugs can be good applied in pediatric tonsillectomy surgery.Sufentanil shows more advantages in improving the recovery quality and security of anesthesia after surgery.