新生儿高胆红素血症对心肌损害的临床分析

王信伟; 杨云

新生儿高胆红素血症对心肌损害的临床分析

王信伟,
杨云

The clinic analysis of myocardial injury in hyperbilirubinemia

摘要

摘要: 目的：研究新生儿高胆红素血症时心肌酶谱、心肌肌钙蛋白 I（cTnI）的变化及表达。方法：选取新生儿高胆红素血症80例作为研究对象（高胆组），选取同期产科住院观察的生理性黄疸新生儿80名作为健康对照组（对照组）。分别采集2组新生儿外周静脉血2 ml，行cTnI、肌酸激酶、肌酸激酶同工酶、天冬氨酸氨基转移酶及总胆红素水平检测。结果：高胆组新生儿血清cTnI阳性率为70.0%，肌酸肌酶同工酶阳性率为46.3%，差异有统计学意义（P<0.01）。高胆组新生儿总胆红素与cTnI水平呈正相关关系（P<0.01）。结论：新生儿高胆红素血症可引起心肌损害，cTnI水平稳定表达，可作为心肌损伤的诊断指标，以便对心肌损伤进行早期诊断和治疗。

Abstract: Objective: To explore the expression of cardiac enzymes and cardiac troponin I(cTnI) in neonatal hyperbilirubinemia.Methods: Eighty neonates with hyperbilirubinemia and 80 neonates with physiological jaundice were divided into the hyperbilirubinemia group and control group.The serum levels of cTnI,creatine kinase,creatine kinase-MB,aspartate aminotransferase and in two groups were measured.Results: The positive rates of cTnI and creatine kinase-MB in hyperbilirubinemia group were 70.0% and 46.3%,respectively,the difference of which was statistically significant(P<0.01).The total bilirubin level was positively correlated with cTnI in hyperbilirubinemia group(P<0.01).Conclusions: High bilirubin can lead to a reversible myocardial injury.The expression of cTnI is stable,which can be used as a criteria in early diagnosis and treatment of myocardial injury.

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