口服华法林患者血浆蛋白质Z水平检测的临床意义

胡微; 汤荣华

口服华法林患者血浆蛋白质Z水平检测的临床意义

胡微,
汤荣华

Clinical significance of plasma protein Z level in patients with taking orally warfarin

摘要

摘要: 目的:观察口服华法林患者血浆蛋白质Z(protein Z,PZ)含量的变化,并探讨其变化发生的原因以及对华法林口服量的监测作用。方法:30例口服华法林患者为一组,23名正常人为对照组,分别进行PZ、血浆凝血酶原时间(prothrombin time,PT)、PT国际标准化比值(PT:INR)测定。PZ用ELISA法检测,PT和PT:INR用全自动血凝仪测定。结果:口服华法林组PZ为(240.87±192.72)ng/ml,明显低于对照组(1 812.6±347.16)ng/ml(P<0.001)。口服华法林组PT为(24.18±4.52)s,明显高于对照组(12.67±0.42)s(P<0.001)。口服华法林组PT:INR值(2.448±0.63)亦明显高于对照组(0.943±0.04)(P<0.001)。结论:口服华法林患者PZ水平明显减低,提示口服华法林可能导致蛋白质Z的缺乏,血浆蛋白质Z水平可作为华法林口服量的一项监测指标。

Abstract: Objective: To observe the alteration of protein Z(PZ) in patients with taking orally warfarin.Research the reason of this alteration and the monitor function of the PZ in pauients with taking orally warfarin.Methods: Thirty patients with taking orally warfarin and 23 healthy adults as the control group,and detect the level of the plasma PZ and prothrombin time(PT),PT:INR.PZ was measured by ELISA and PT,PT:INR were measured by stago auto-analyor.Results: In taking orally warfarin group PZ levels was(240.87±192.72) ng/ml.It compared with health group's PZ level(1 812.6±347.16) ng/ml has dropped(P<0.001).Taking orally warfarin group's PT(24.18±4.52) s compared with health group's PT(12.67±0.42) s has raised(P<0.001).Taking orally warfarin group's PT:INR(2.448±0.63) compared with health group's PT:INR(0.943±0.04) has raised(P<0.001).Conclusions: PZ level of the patients who take orally warfarin is obrions drop.Fingdings shows that taking orally warfarin could make the PZ drop.The plasma protein Z level can be used as an indicator to monitor the amonnt of warfarin.

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