Objective To evaluate the predictive value of systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), acute-phase inflammation score index (AISI) and prognostic nutritional index (PNI) for the prognosis of triple-negative breast cancer (TNBC) patients.

Methods The clinical data of 100 TNBC patients treated with first surgery were retrospectively analyzed. The optimal cut-off values of SII, SIRI, AISI, and PNI for predicting the prognosis of TNBC patients were analyzed by ROC curve. The disease-free survival (DFS) of patients among different groups were compared by Kaplan-Meier method and Log-Rank test. Cox regression analysis was used to evaluate the independent prognostic factors of TNBC patients.

Results The AUCs of SII, SIRI, AISI, and PNI were 0.719, 0.726, 0.621, and 0.821, respectively (P ＜ 0.05). The DFS was prolonged in the low SII (≤481.9), low SIRI (≤0.702), low AISI (≤137.6), and high PNI (≥51.28) groups (P ＜ 0.05). The results of Multivariate analysis showed that the T stage, N stage, SII, SIRI, AISI and PNI were the independent prognostic factors of DFS in TNBC patients (P ＜ 0.05 to P ＜ 0.01).

Conclusions The combination of systemic inflammatory markers and nutritional indices can be used as an effective tool for the prognosis assessment of TNBC.