Abstract: Objective: To observe and evaluate the effect of curcumin on content of hydroxyproline in the epidural scar tissue of rats after laminectomy,and to explore its mechanism.Methods: Thirty-six SD rats with 0.3 cm×0.5 cm epidural exposed area after L₁ laminectomy surgery were randomly divided into 3 groups.The control group (group A) received no treatment;the collagen sponge group (group B) and the curcumin collagen sponge group (group C) were respectively placed 0.5 cm×0.7 cm collagen sponge and collagen sponge absorbing curcumin dimethyl sulfoxide solution (0.25 g/ml) in the laminectomy defect.Four weeks later,the level of hydroxyproline in the scar tissue was determined,and the degree of peridural adhesion was generally evaluated according to the Rydell standard.Results: The content of hydroxyproline in group B and group C was lower than that in group A (P<0.05 and P<0.01).Conclusions: Curcumin can reduce epidural scar production and inhibit the formation of collagen fibers.