乳腺癌Ki-67抗原表达与腋淋巴结转移和组织学分级的关系

傅晓艳

乳腺癌Ki-67抗原表达与腋淋巴结转移和组织学分级的关系

傅晓艳

Relationship between the axillary lymph nodes metastases, histological grading and the expression of Ki-67 antigen in breast carcinomas

FU Xiao-yan

摘要

摘要: 目的: 探讨乳腺癌Ki-67抗原表达与腋淋巴结转移和组织学分级的关系。方法: 乳腺癌标本108例,腋淋巴结转移者48例,组织学分级Ⅱ级40例,Ⅲ级68例。S-P法免疫组化染色活检石蜡组织切片。结果: 乳腺癌腋淋巴结转移阳性患者其Ki-67过度表达率以及c-erbB-2阳性表达率均高于腋淋巴结转移阴性患者(P<0.005和P<0.01);乳腺癌组织学分级Ⅲ级患者其Ki-67过度表达率以及c-erbB-2阳性表达率高于组织学分级Ⅱ级患者(P<0.005和P<0.05);Ki-67过表达的乳腺癌其c-erbB-2阳性表达率显著高于Ki-67低表达者(P<0.005)。结论: Ki-67过度表达是预后不良的指标之一。

Abstract: Objective: To study the relationship between axillary lymph nodes metastases,histological grade and the expression of Ki-67 antigen in breast cancer.Methods: Immunohistochemistry assay was used to study the expression of Ki-67 antigen in 108 patients with breast cancer.Results: The overexpression rate of Ki-67 antigen and the positive rate of c-erbB-2 in the positive axillary lymph nodes metastases group were higher than those in the negative group(P<0.005 and P<0.01).The overexpression rate of Ki-67 antigen and the positive rate of c-erbB-2 in the histological grade Ⅲ group were higher than those in the gradeⅡ group(P<0.005 and P<0.05).The positive rate of c-erbB-2 in the Ki-67 antigen overexpressed patients were significantly higher than that in the low expressed group(P<0.005).Conclusions: Overexpression of Ki-67 antigen may be one of the poor prognostic indexes for breast cancer.

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