痢疾杆菌51株耐药性分析

朱贞祥; 李家斌

痢疾杆菌51株耐药性分析

Analysis to drug resistance of Dysenteric bacilli: A report of 51 cases

摘要

摘要: 目的:观察痢疾杆菌的耐药性,指导临床医师选择合理、有效的抗生素。方法:选择细菌性痢疾患者分离出的痢疾杆菌51株,K-B法检测细菌的药物敏感性。结果:痢疾杆菌对磺胺甲噁唑、氨苄西林、诺氟沙星、头孢曲松等抗生素有较高的耐药性,耐药率分别为78.4%、60.8%、29.1%及23.5%;而对阿米卡星、磷霉素、氧氟沙星、哌拉西林、头孢哌酮及呋喃唑酮等抗生素较敏感,敏感性分别为78.4%、88.2%、84.3%、86.3%、92.2%及94.1%。结论:痢疾杆菌对磺胺甲噁唑、氨苄青霉素及诺氟沙星耐药性较高,临床使用无效,而对三代头孢菌素、磷霉素、阿米卡星及氧氟沙星等敏感,可用于细菌性痢疾的治疗;另外呋喃唑酮对痢疾杆菌的敏感性明显增加,可以选用。

Abstract: Objective: To study the drug resistance of Dysenteric bacilli so as to guide the physicians to choose effective antibiotics.Methods: Dysenteric bacilli were isolated from the stools of 51 patients,and Kirby-Bauer method was used to test their sensitivity to antibiotics.Results: Dysenteric bacilli were highly resistant to sulfamethoxazole(78.4%),ampicillin(60.8%),norfloxacin(29.1%) and ceftriaxone(23.5%),but were sensitive to amikacin(78.4%),phosphonomycins(88.2%),ofloxacin(84.3%),piperacillin(86.3%),cefoperazone(92.2%) and furazolidone(94.1%).Conclusions: Dysenteric bacilli is highly resistant to sulfamethoxazole,ampicillin and norfloxacl,but sensitive to the third generation cephalosporins,phosphonomycins,amikacin and ofloxacin.Furazolidone is another chioce,for its sensitivity to Dysenteric bacilli is greatly increasing.

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