Abstract: Objective: To study the efficacy of injection in mucosa of hydroxycamptothecin(HCPT) for prevention of postoperative recurrence of superficial bladder cancer.Methods: Sixty-five cases superficial bladder cancer in our hospital were divided into observation(A) group including 33 cases and control(B) group including 32 cases.The cases of A group were injected in submucosa then instillated.The B group only were treated with intravesical instillation.Results: Sixty-five cases had been followed up for 2 to 6 years.There was only 1 case of recurrence within 54 months,recurrence rate of 3.0%,in A group.There were 6 cases of recurrence,recurrence rate of 18.7%,in B group.Compared with B group the recurrence rate of A group is low(P<0.05).Conclusions: Injection in submucosa of HCPT can effectively prevent postoperative recurrence of superficial bladder cancer with less side effects.