Efficacy of injection in submucosa of hydroxycamptothecin for prevention of postoperative recurrence of superficial bladder cancer
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摘要: 目的:观察术中黏膜下注射羟基喜树碱对浅表性膀胱癌预后的疗效。方法:65例浅表性膀胱癌,33例为观察组,接受羟基喜树碱术中膀胱黏膜下注射,术后喜树碱膀胱灌注。32例为对照组,单纯行术后常规膀胱内羟基喜树碱灌注治疗。结果:65例均获随访,随访时间2~6年。观察组在4年6个月时仅有1例复发,复发率为3.0%;对照组在随访期间共有6例复发,复发率18.8%,高于观察组(P<0.05)。观察组无瘤生存率高于对照组。结论:羟基喜树碱术中黏膜下注射能有效降低浅表性膀胱癌术后复发率,提高患者无瘤生存率。Abstract: Objective: To study the efficacy of injection in mucosa of hydroxycamptothecin(HCPT) for prevention of postoperative recurrence of superficial bladder cancer.Methods: Sixty-five cases superficial bladder cancer in our hospital were divided into observation(A) group including 33 cases and control(B) group including 32 cases.The cases of A group were injected in submucosa then instillated.The B group only were treated with intravesical instillation.Results: Sixty-five cases had been followed up for 2 to 6 years.There was only 1 case of recurrence within 54 months,recurrence rate of 3.0%,in A group.There were 6 cases of recurrence,recurrence rate of 18.7%,in B group.Compared with B group the recurrence rate of A group is low(P<0.05).Conclusions: Injection in submucosa of HCPT can effectively prevent postoperative recurrence of superficial bladder cancer with less side effects.
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Keywords:
- bladder neoplasms /
- carcinoma,transitional cell /
- hydroxycamptothecin /
- recurrence
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