缺氧缺血性脑病新生儿血浆中血管内皮生长因子动态变化的临床意义

徐双云; 徐家丽; 沈怀云; 周瑞; 孔平

缺氧缺血性脑病新生儿血浆中血管内皮生长因子动态变化的临床意义

Significance of the changes of vascular endothelial growth factor in neonates with hypoxic ischemic encephalopathy

摘要

摘要: 目的:观察缺氧缺血性脑病(hypoxic ischemic encephalopathy,HIE)新生儿血浆中血管内皮生长因子(vascular endothelial growth factor,VEGF)含量的动态变化,探讨VEGF与HIE发病机制及早期诊断的临床相关性。方法:选择90例确诊为HIE的足月新生儿作为观察组(HIE组),酶联免疫吸附试验分别测定出生后第1天、第3天(急性期)和第7天(恢复期)血浆VEGF;同时测定30例无神经系统疾病的足月新生儿(对照组)出生后第1天、第3天、第7天的血浆VEGF。结果:HIE组患儿血浆VEGF在出生后第1天、第3天和第7天均显著升高,与对照组差异有统计学意义(P<0.01);第1天达高峰,以后下降,与第7天比较,差异有统计学意义(P<0.01)。结论:VEGF变化对判断有无HIE有重要意义。

Abstract: Objective: To observe the dynamic changes of vascular endothelial growth factor(VEGF) in the blood plasma of the newborns with hypoxic ischemic encephalopathy(HIE),and to investigate the correlation of VEGF with the pathogenesis and early diagnosis of HIE.Methods: Ninety full-term newborns with HIE were chosen as the experimental group,and the VEGF in plasma was examined on the 1st day,the 3rd day(acute stage) and the 7th day(the recovery stage) after birth using enzyme linked immunosorbent assay(ELISA);30 neonates with no nervous system diseases acted as control.Results: VEGF in the experimental group on the 1st day,3rd day and 7th day after birth increased significantly compared with that in the control(P<0.01),and it reached the peak on the 1st day,and then descended.The VEGF on the first day was much higher than that on the 7th day(P<0.01).Conclusions: VEGF can be used as a significant index in diagnosis of HIE.

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