Abstract: Objective: To explore the nursing measures of propofol in patients with mechanical ventilation in intensive care unit (ICU).Methods: Thirty-eight patients were received propofol after being mechanically ventilated in ICU.The sedative effectiveness were observed, and the indices of respiration and circulation which were monitored dynamically in process of using drug, and till drug was stopped were compared with those observed before using it.Results: Compared with before using propofol, RR, HR, PaCO₂ in process of using and stopping drug decreased significantly (P<0.01), while pH, PaO₂, SaO₂ increased significantly (P<0.05-P<0.01).Complication and accident had not happened in 38 patients.Conclusions: As a sedative, propofol is safe and effective for the patients with mechanical ventilation in ICU.through intensive care, the nursing complication and accident can be avoided completely.