Abstract: Objective: To survey and analyze the curreut status of proton pump inhibitor(PPI) for treatment of peptic ulcer and erosive gastritis in Anhui Province.Methods: The therapeutic data of peptic ulcer erosive gastritis from Anhui Province and the national contrast analyxed.Results: The infection rate of Helicobacter pylori(Hp) in peptic ulcer and erosive gastritis was significant difference between Anhui Province and entire country(P<0.01).The total effective rate which Anhui Province used Hp eradication and maintenane therapy was significantly higher than the whole country.The difference was significant(P<0.05);while in peptic ulcer with positive Hp,erosive gastritis with positive or negative Hp.The therapeutic regimens against Hp was no significant difference(P>0.05).Conclusions: Using Hp eradication and maintenane therapy-predominant treatment in peptic ulcer,which is on of the most effection methods in Anhui Province.