大剂量丙种球蛋白治疗小儿重症病毒性脑炎临床分析

Clinical analyses of high dose immunoglobulin in treatment of severe viral encephalitis in children

摘要: 目的: 观察静脉滴注大剂量丙种球蛋白(HDIG)治疗小儿重症病毒性脑炎(SVE)的临床疗效。方法: 38例SV E分为HDIG治疗组16例和对照组22例,治疗组在对照组常规治疗的基础上静脉滴注HDIG(400 mg·kg^-1·d^-1),并观察患儿的临床症状、体征消失的时间及住院时间。结果: 治疗组止痉时间、神志开始恢复时间、退热时间短于对照组(P<0.05~P<0.01),住院时间与对照组差异无显著性(P>0.05)。结论: HDIG治疗SVE能减轻脑组织损害,缩短疗程,临床疗效好。

Abstract: Objective: To evaluate the efficacy of high dose immunoglobulin in treatment of severe viral encephalitis in children.Methods: Thirty-eight children were divided into study group(n=16) treated with intravenous high dose immunoglobulin and control group(n=22).The clinical symptoms,physical signs and the time of hospital stay were observed and compared.Results: It took less time for the study group to bring down a fever,stop spasm and regain consciousness than it did for the control group(P<0.05 to P<0.01),and no difference was found in the time of hospital stay between the two groups(P>0.05).Conclusions: Intravenous high dose immunoglobulin can relieve brain tissue damage and is effective in treating severe viral encephalitis of children.