甲型副伤寒21例临床特征和药敏分析

陈天平; 蒋连红

甲型副伤寒21例临床特征和药敏分析

Analysis of the clinical features and drug sensitivity of 21 cases patients with paratyphoid A

摘要

摘要: 目的: 探讨甲型副伤寒的临床特征和药物敏感特点。方法: 回顾性分析21例甲型副伤寒患者(副伤寒组)的临床特征和药敏特点,与在中国学术期刊(光盘版)随机查找1994~1996年度的伤寒文献级(伤寒组)相比较。结果: 伤寒组和副伤寒组有伤寒及副伤寒中典型特征者、明显全身中毒症状者、相对缓脉、表情淡漠及脾肿大的发生率分别为86.1%、62.5%、36.4%、51%、12.6%和4.8%、38.1%、9.5%、52.9%,差异均有统计学意义(P<0.05~P<0.01);发热、玫瑰疹及肝肿大的发生率分别为99.1%、14.1%、19.1%和100.0%、9.5%、29.4%,差异均无统计学意义(P>0.05)。副伤寒组喹诺酮类药物敏感率100.0%,三代头孢敏感率90%以上。结论: 甲型副伤寒临床症状不典型,中毒症状轻,脾肿大、相对缓脉和表情淡漠较多见。治疗首选喹诺酮类药物,次选第三代头孢菌素、氯霉素。

Abstract: Objective: To analyze the clinical features and drug sensitivity of paratyphoid A.Methods: Twenty-one cases of paratyphoid A were analyzed retrospectively.The clinical features and drug sensitivity were compared with the cases selected randomly in Chinese Academic Journal(CD) from 1994-1996.Results: The presentation of typical characteristics of typhoid and paratyphoid was 86.1 and 4.8 in the typhoid group and paratyphoid A group respectively;obvious toxic symptoms were observed in 62.5 of the patients in the typhoid group and 38.1 in the paratyphoid A group;The incidence of relative infrequent pulse was 36.4 and 9.5 in the typhoid group and paratyphoid A group respectively;The apathia rate was 51 in the typhoid group and 9.5 in the paratyphoid A group;The incidence rate of enlarged spleen was 12.6 and 52.9 in the typhoid group and paratyphoid A group respectively(P<0.05~P<0.01).The difference was significant.The incidence of fever,rose rash and hepatauxe was 99.1, 14.1 and 19.1 in the typhoid group and 100,9.5 and 29.4 in the paratyphoid A group,respectively;the difference was not significant (P>0.05).The sensitiveness rate of quinolones was 100 and the sensitiveness rate of the third generation ephamycins was above 90.Conclusions: Clinical symptoms of paratyphoid A are not typical.Quinolones is the first medicine for treatment of paratyphoid A,and the third generation ephamycins and chlormycetin are the second choice.

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