Abstract: Objective: To explore the effect and side-effect of somatostatin on portal hypertension caused by hepatocirrhosis,and on the rupture of veins induced by varicosity at the lower sect of oesophagus and the fundus of stomach.Methods: Forty cases of hepatocirrhosis who had portal hypertension combined with rupture of veins due to varicosity at the lower sect of oesophagus and the fundus of stomach were randomly divided into two groups:control group(22 cases) and treatment group(18 cases).The control group and the treatment group were administered posterior pituitrin or somatostatin in addition to the routine therapy(such as acid-ridding,liverprotecting,pressure-lowering of portal vein and fluid-supplying).The hemostasis and side-effects were observed in the two groups.Results: The response rates of the treatment group and the control group were 68.2%,and 88.9%,respectively.The difference was significant(P<0.05);Moreover,the treatment group demonstrated less side-effect and better toleration.Conclusions: It is concluded that somatostatin has a good curative effect on first vein rupture caused by portal hypertension due to hepatocirrhosis and varicosity at the lower sect of oesophagus and the fundus of stomach.It is worth popularizing.