氯化锶治疗转移性骨肿瘤疗效评价

    Palliative effect of 89SrCl on metastatic carcinoma of bone

    • 摘要: 目的: 观察氯化锶(89SrCl)治疗转移性骨肿瘤的疗效。方法: 对22例骨转移性癌患者按体重静脉推注89SrCl 1.48~2.22 MBq/kg,观察患者的疼痛缓解、病灶变化及副作用,并进行影像学和血清肿瘤标志物的随访。结果: 18例患者骨痛消失或减轻,骨转移癌疼痛总缓解率为81.8%,部分患者骨转移灶缩小、消失,血清肿瘤标志物和碱性磷酸酶下降。结论: 89SrCl对骨转移癌疼痛有缓解作用,并可缩小病灶,副作用小。

       

      Abstract: Objective: To evaluate the effect of 89SrCl therapy on patients with metastatic carcinoma of bone.Methods: Twenty-two patients were treated by intravenous 89SrCl at a dose of 1.48-2.22 MBq/kg.The bone-pain,lesion and the side-effect were observed.The imaging and serum tumor makers were followed up.Results: The bone-pain vanished or eased in 18 cases after the therapy.The response rate was 81.8%.The lesions became small or vanished in some patients and the serum tumor markers and alkaline phosphates(AKP) came down.Conclusions: 89SrCl has obvious effect on patients with metastatic carcinoma of bone and the side-effect is mild.

       

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