Objective To investigate the relationship between ligation depth and the efficacy of peroral endoscopic cardial constriction in the treatment of gastroesophageal reflux disease (GERD).

Methods A total of 32 patients with gastroesophageal reflux disease underwent endoscopic cardia coarctation, and the patients without muscularis propria were divided into group A and group B according to whether there were changes in the muscularis propria under ultrasound gastroscopy, and the Gerd-Q scores of the two groups before treatment and 6 months after treatment were compared. Before treatment and 6 months after treatment, 24-hour esophageal pH monitoring, DeMeester score, and percentage of acid exposure (AET) were performed.

Results There were no significant differences in Gerd-Q score, DeMeester score and AET between group A and group B before treatment (P ＞ 0.05), and the Gerd-Q score, DeMeester score and AET in the two groups were lower than those before operation (P ＜ 0.05) at 6 months after treatment, and there was no significant difference between groups (P ＞ 0.05). Group A showed marked improvement in 5 cases and improvement in 8 cases, whereas Group B had 4 cases of marked improvement and 15 cases of improvement. There was no significant difference in response rate between groups (P ＞ 0.05).

Conclusion The short-term efficacy of endoscopic cardia coarctation in the treatment of refractory gastroesophageal reflux disease is significant, and the depth of banding may not be the main factor affecting the efficacy.