部分性脾栓塞术治疗肝硬化脾功能亢进

Partial splenic embolization in treatment of hypersplenism followed by liver cirrhosis

摘要: 目的: 探讨部分性脾栓塞术(partial splenic embolization,PSE)治疗肝硬化脾功能亢进(脾亢)的临床价值。方法: 20例肝硬化脾功能亢进患者,使用明胶海绵颗粒(1 mm×1 mm×1 mm)栓塞,栓塞程度50%~70%。结果: 术后1天白细胞即可回升,白细胞和血小板计数分别于术后3天和2周达到峰值,随后逐渐下降,术后1个月趋于稳定,恢复至正常水平或基本接近正常。无严重术后不良反应和并发症。结论: 栓塞程度控制在50%~70%的PSE能有效治疗肝硬化脾功能亢进。

Abstract: Objective: To study the clinical significance of partial splenic embolization(PSE) in treatmeot of hypersplenism with liver cirrhosis.Methods: Twenty patients with liver cirrhosis and hypersplenism were treated with gelfoam(1 mm×1 mm×1 mm).The embolization degree ranged from 50% to 70%.Results: White blood cell(WBC) count increased immediately on the first day after PSE.WBC and Platelet(PLT) counts reached peak level on the third day and in the second week respectively after PSE,and then decreased gradually.WBC and PLT counts were normal or close to normal after one month.Neither severe side effects nor complications occurred.Conclusions: The embolization of the degree ranging from 50% to 70% may alleviate hypersplenism in patients with liver cirrhosis.