李冰冰, 董志远, 姜杉, 周琪, 邓琳琪, 成希明, 赵娟. 缺血修饰白蛋白在急性冠状动脉综合征早期诊断中的应用[J]. 蚌埠医学院学报, 2011, 36(5): 456-458.
    引用本文: 李冰冰, 董志远, 姜杉, 周琪, 邓琳琪, 成希明, 赵娟. 缺血修饰白蛋白在急性冠状动脉综合征早期诊断中的应用[J]. 蚌埠医学院学报, 2011, 36(5): 456-458.
    LI Bing-bing, DONG Zhi-yuan, JIANG Shan, ZHOU Qi, DENG Lin-qi, CHENG Xi-ming, ZHAO Juan. Role of ischemia modified albumin in early diagnosis of acute coronary syndrome[J]. Journal of Bengbu Medical College, 2011, 36(5): 456-458.
    Citation: LI Bing-bing, DONG Zhi-yuan, JIANG Shan, ZHOU Qi, DENG Lin-qi, CHENG Xi-ming, ZHAO Juan. Role of ischemia modified albumin in early diagnosis of acute coronary syndrome[J]. Journal of Bengbu Medical College, 2011, 36(5): 456-458.

    缺血修饰白蛋白在急性冠状动脉综合征早期诊断中的应用

    Role of ischemia modified albumin in early diagnosis of acute coronary syndrome

    • 摘要: 目的:探讨缺血修饰白蛋白(IMA)在急性冠状动脉综合征(ACS)早期诊断中的价值。方法:采取ACS组56例、非缺血性胸痛(NICP)组30例患者发病3 h内和155名健康体检者(对照组)静脉血,检测并比较3组标本的IMA、MB型肌酸激酶(CK-MB)、心肌肌钙蛋白I(cTnI)水平,应用ROC分析评价各心肌标志物在ACS早期诊断中的效能。结果:3组IMA分别为(0.500±0.017)、(0.400±0.082)、(0.326±0.024)吸光度单位,ACS组与对照组和NICP组比较,IMA水平差异均有统计学意义(P<0.01)。ROC曲线下面积IMA > cTnI > CK-MB,最佳截断点时的灵敏度IMA > CK-MB > cTnI,特异度IMA > cTnI > CK-MB;与NICP组比较,IMA阳性似然比为10.7,阴性似然比为0.008;与对照组比较,IMA阳性似然比8.23,阴性似然比0.013。结论:IMA对ACS早期诊断效能优于cTnI和CK-MB。

       

      Abstract: Objective: To estimate the value of ischemia modified albumin(IMA) in early diagnosis of acute coronary syndrome(ACS).Methods: The venous blood samples from 56 patients with ACS(ACS group),30 patients with non-ischemia chest pain(NICP group) within 3 h of onset and 155 healthy controls were assayed,and the IMA,MB type creatine kinase(CK-MB) and cardiac troponin(cTnI) levels were compared among the three groups.The value of the myocardial markers in early diagnosis of ACS was estimated by the ROC curve.Results: The IMA of the 3 groups were(0.500±0.017),(0.400±0.082) and(0.326±0.024) absorbance unit,respectively;the serum level of IMA in ACS group was higher than that in healthy controls and NICP group(P<0.01).The area under curve of IMA was larger than that of cTnI and CK-MB;the sensitivity of IMA was higher than that of CK-MB and cTnI;the specificity of IMA was more obvious than that of cTnI>CK-MB.The best cutoff value of IMA,CK-MB and cTnI was definite.Compared with the NICP group,the positive likelihood ratio and negative likelihood ratio of IMA for ACS were 10.7 and 0.008,respectively;compared with the healthy controls,the positive likelihood ratio and negative likelihood ratio of IMA for ACS were 8.23 and 0.013,respectively.Conclusions: IMA is superior to cTnI and CK-MB in diagnostic of ACS at the early stage.

       

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