Abstract: Objective: To evaluate the efficacy and safety of endovascular stent-graft exclusion in treatment of thoracic and abdominal aneurysms.Methods: Seven patients with thoracic and abdominal aneurysms underwent endovascular stent-graft exclusion under general anaesthesia or basic anaesthesia.Home-made stent-grafts were used in 6 cases with thoracic aortic disease and TALENT bifurcated stent-graft was used in 1 case.Results: The pseudocoele and aneurysm in 6 cases were effectively isolated and the ulcer in 1 case healed.CT angiography showed that no endoleak or stent-graft disposition occurred and all the patients were capable of normal physical work after operation.Conclusions: Endovascular stent-graft exclusion can be used for treatment of thoracic and abdominal aneurysms.It is a promising microoperation therapy.