Abstract: Objective:To observe the clinical therapeutic effects,safety and resistance of insulin analogue aspart 30 in treatment for type 2 diabetes mellitus.Methods:Forty patients with type 2 diabetes mellitus.were randomly divided into A group and B group,aspart 30 was used in A group patients while novolin 30R was used in B group patients,A group and B group patients were treated twice daily in morning and evening respectively.And the drug doses were adjusted momentarily according to the concentration of blood glucose in these patients.These parameters including the concentration of fasting plasma glucose (FPG),concentration of 2 hours postprandial glucose (2hPG),therapeutic time,insulin dose and the level of hypoglycemia were compared between these two groups.Results:Aspart 30 and novolin 30R could decrease the concentration of blood glucose efficiently (P<0.01),and there were no significant differences in these two groups (P>0.05).The level of hypoglycemia in aspart 30 group was higher than in novolin 30R group (P<0.05),especially the level of severe hypoglycemia at night.Conclusions:Aspart 30 is an effective and high safety drug in treatment for type 2 diabetes mellitus.The resistance and compliance of aspart 30 is better than novolin 30R.