Abstract: Objective: To investigate the effects of 40 mg and 80 mg fluvastatin on the coronary artery plaques,and levels of serum lipids and high sensitive C-reactive protein(hs-CRP) in patients with coronary heart disease,and its safety.Methods: One hundred and twenty patients with coronary heart disease were randomly divided into A group(treatment with 80 mg fluvastatin every night),B group(treatment with 40 mg fluvastatin every night) and C group(treatment with other fluvastatin and hypolipidemic drugs)(40 cases each group),and the treatment course of all cases was 6 months.The computed tomography coronary angiography in all patients was examined to calculate the coronary artery plaques before and after treatment.The serum levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),hs-CRP and liver function in all cases were measured.Results: The differences of the serum levels of TC,TG,LDL-C,HDL-C and hs-CRP between three groups before treatment were not statistical significance(P>0.05).Compared with before treatment,the serum levels of hs-CRP,TC,TG and LDL-C in A and B groups in 6 months after treatment decreased(P<0.01),but for the level of HDL-C,it increased(P<0.01).The level of LDL-C in A group after treatment was lower than that in B group(P<0.01).After treatment,the number of fatty plaques,and the number of fibre and calcified plaques in coronary artery of A and B groups decreased and increased,respectively,the differences of whose between three groups were not statistical significance(P>0.05).Conclusions: The treatment of coronary heart disease with fluvastatin can significantly reduce the serum levels of hs-CRP and blood lipid,inhibit inflammation,and stabilize and regress the plaque of coronary artery heart.The effect of A group is better than that of B group.