Abstract: Objective: To identify the predictors correlated with the prognosis 90 days after acute progressive ischemic stroke.Methods: One hundred and fifty-five acute progressive ischemic stroke patients within 24 hours after onset were enrolled into the study during Feb.2011 to Dec.2012.The demographic data,past history,laboratory examination and imaging studies were recorded.The neurologic deficit scores at admission to hospital,symptomatic progression period and 90 days'period were assessed using U.S National Institutes of Health stroke scale(NIHSS),Glasgow coma scale(GCS) and modified Rankin scale(mRS).Results: There were statistical significant differences about C reactive protein within 24 hours,blood glucose level,fibrinogen,erythrocyte sedimentation rate,baseline GCS and NIHSS scores and hospitalization infection in patients at 90 days mRS clinical outcome(P<0.05 to P<0.01).Conclusions: The factors including C reactive protein,blood glucose level,fibrinogen,erythrocyte sedimentation rate,GCS and NIHSS scores,infection were correlated with 90 days mRS clinical outcome.In clinical treatment,control these factors can improve the outcome.