Abstract: Objective: To evaluate the feasibility and clinical results of postoperative analgesia by incisional infiltration of lornoxicam. Methods: Forty-five patients with head and neck surgery were chosen. Five patients required postoperative analgesia and the remaining were divided into group A and group B with 20 cases each. Group A:8 mg lornoxicam dissolved in 0.9% 20 ml normal saline,before suture,patients were injected by the layers of tissue within the incision; Group B:No special treatment,the incision was sutured directly; Group C:48 mg lornoxicam combined with 100 μg sufentanil dissolved in 0.9% saline to 100 ml, postoperative patient-controlled intravenous analgesia. Record pain score,drug-related side effects,wound healing and patient satisfaction immediately,1,6,12,24 hours after each operation. Results: Pain score of group A, C were significantly lighter than group B (P<0.01),1 case of group C postoperative vomiting. Three wounds were Ⅰ healed. Three satisfaction surveys are very satisfied and satisfied. Conclusions: Lornoxicam promised a good analgesic effect of infiltration and could be used for superficial incision for postoperative analgesia.