Abstract: Objective: To explore the clinical effects of postoperative chemoradiation and radiotherapy on advanced hypopharyngeal carcinoma.Methods: Thirty-seven patients with advanced hypopharyngeal carcinoma(including 20 cases with laryngeal function and 17 cases without laryngeal function) were treated with radiotherapy after surgery(radiotherapy group),35 patients with advanced hypopharyngeal carcinoma(including 24 cases with laryngeal function and 11 cases without laryngeal function) were treated with chemoradiation after surgery(chemoradiation group).The survival rate and life quality of two groups were compared,and the survival rate of patients with and without laryngeal function was compared.Results: The 3-year and 5-year survival rates in radiotherapy group and chemoradiation group were 48.65% & 71.43% and 24.32% & 48.57%,respectively,the difference of which was statistically significant(P<0.05).The differences of the incidence rates of toxicity and pharyngeal fistula,and the swallowing function and linguistic function recovery in two groups were not statistically significant(P>0.05).The 3-year and 5-year survival rates in patients with and without without laryngeal function were 40.90% & 60.71% and 27.27% & 39.28%,respectively,the difference of which was not statistically significant(P>0.05).Conclusions: The survival rates of 3-and 5-year of patients with advanced hypopharyngeal carcinoma treated with chemoradiation are higher than those of patients treated only with radiotherapy,the treatment does not increase the toxicity and affect the life quality of postoperative patients.The survival rates of 3-and 5-year of patients with and without laryngeal function are similar,and the laryngeal function can be preserved according to the disease.