Abstract: Objective: To investigate the effect of the continued treatment(including pharmaceuticals and non-pharmaceuticals) on prognosis of newborn with hypoxic ischemic encephalopathy(HIE).Methods: One hundred and eight newborns with the middle and serious HIE were divided into the observation group(69 cases) and the control group(39 cases)(Group C).The observation group was further divided into Group A(37 cases) and Group B(32 cases).Group A and B underwent same early intervention.Group A was also administered with three courses of the pharmaceuticals cerebroprotein hydrolysate injection after the newborn stage.The newborns in the control group were brought up routinely.They were followed up at one month,six months and twelve months interval.MDI and PDI of the 3 groups were compared at twelve months interval.Results: MDI was 92.027±8.48,87.844±7.89 and 83.821±8.693 for Group A,B and C respectively.PDI was 93.216±9.096,88.500±8.474 and 84.231±9.068 for Group A,B and C respectively with significant differences(P<0.05~P<0.01)Conclusions: The continued treatment can improve HIE prognosis.The pharmaceuticals treatment combined with early intervention is better than the simple early intervention treat.