皮肤镰刀菌感染16例汇集分析

    A collective analysis of 16 cases of skin Fusarium infection

    • 摘要: 目的:探讨皮肤镰刀菌感染临床特点、预防及诊治经验。方法:对2001~2013年国内报道的皮肤镰刀菌感染16例进行汇集分析。结果:茄病镰刀菌感染10例,串珠镰刀菌感染3例,尖孢镰刀菌感染1例,菌种不明2例。出现皮肤溃疡12例,皮肤结节3例,同时出现皮肤溃疡及皮肤结节1例。播散性镰刀菌感染1例;基础疾病为急性白血病2例,合并皮肤鳞状细胞癌1例。真菌培养阳性16例,直接镜检发现真菌11例,病理检查发现真菌7例。全身抗真菌治疗11例,好转或痊愈8例。结论:皮肤镰刀菌感染以茄病镰刀菌最多见,皮肤呈溃疡或结节样改变多见。真菌培养、直接镜检及组织病理学检查有助诊断,治疗尚无统一方案。

       

      Abstract: Objective:To investigate the clinical features and treatment of skin Fusarium infection.Methods:Sixteen cases of skin fusariun infections reported in China from 2001 to 2003 were collected and analyzed.Results:There were 10 cases of Fusarium solani infection,3 cases of Fusarium moniliforme infection,1 case of Fusarium oxysporum infection and 2 cases of unknown species in this group.Skin ulcer occurred in 12 cases,skin nodules in 3 cases,and skin ulcer and nodules in 1 case.One case presented disseminated Fusarium infection,2 cases the basic disease of acute leukemia and 1 case was complicated with squamouscell carcinoma.Fungal culture was proved positive in 16 cases;fungal component was detected by direct microscopy in 11 cases and by pathological examination in 7 cases.11 cases were treated with systemicantifungal therapy,and 8 of them were improved or cured.Conclusions:Fusarium solani is most commonly seen in Fusarium infection,presenting the symptoms of skin lesion,ulcer or nodular changes in general.Fungal culture,direct microscopic examination and histopathology examination are helpful to the diagnosis.There is no unified treatment protocol for Fusarium infection up to now.

       

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