Abstract: Objective:To explore the effects of fiber bronchoscope(FOB) and Lightwand wand on the hemodynamics of patients with difficult tracheal intubation through the mouth.Methods:Fifty patients with difficult airway treated with surgery through tracheal anesthesia were randomly divided into FOB group(F group) and Light wand group(L group).The systolic pressure,diastolic blood pressure,heart rate,pulse oxygen saturation in two groups were observed before anesthesia induction(T0),before intubation(T1),endotracheal intubation(T2),and at 1 minute(T3),3 minutes(T4) and 5 minutes(T5) after intubation,and the total time of endotracheal intubation,successful intubation cases and postoperative complications in two groups were recorded.Results:The endotracheal intubation success rate in F group and L group were 100.0% and 92.0%,respectively,the difference of which had no statistical significance(P>0.05).The differences of the incidences of postoperative voice hoarse and sore throat between two groups had no statistical significance(P>0.05).The total time of endotracheal intubation in F group was significantly less than that in L group(P2 and T3(PPConclusions:Compared with Lightwand,the effect of FOB on hemodynamics is smaller.Both FOB and Lightwand are effective methods to solve the difficult tracheal intubation.