Abstract: Objective: To observe the short-term effects and adverse reactions of the gimeracil and oteracil porassium capsule(S-1) or capecitabine combined with oxaliplatin in the treatment of advanced gastric cancer.Methods: Forty-eight patients with advanced gastric cancer were randomly divided into the S-1 group and capecitabine group.The S-1 group were treated with 60 mg of gimeracil and oteracil porassium capsule(the body surface area more than or equal 1.25 m²) twice a day for 14 days,3 weeks for a schedule.The capecitabine group were treated with 1 250 mg/m² of capecitabine twice a day for 14 days,3 weeks for a schedule.The 85 mg/m² of oxaliplatin were administered in two groups on the first day.The efficacy was evaluated by CT scan after 2 cycles.Results: The effective rates and tumor growth control rates in S-1 group and capecitabine group were 62.5% ＆ 79.2% and 58.3% ＆ 83.3%,respectively.The differences of effects and adverse reactions between two groups were not statistical significance(P>0.05).The blood platelet decreasing 3 to 4 grade in S-1 group and hemameba decreasing 3 to 4 grade in capecitabine group were found.The less side effects,good tolerance and no death case were observed.Conclusions: The gimeracil and oteracil porassium capsule or capecitabine combined with oxaliplatin in the treatment of advanced gastric cancer is good effect and less adverse reactions.