Abstract: Objective:To compare the the controlling results of early morning hypertension by amlodipine besylate and valsartan.Methods:200 patients with essential hypertension in self-management hypertensive patients in community were selected.Then 88 morning hypertensive patients were screened out.And antihypertensive medications originally were abandoned for 14 days.The patients were divided into two groups randomly.And 41 patients were asked to take amlodipine besylate as the experimental group,while the other 47 patients taking valsartan as controlling group.The morning blood pressure for four weeks(home self-test blood pressure) were observed to understand the controlling results of early morning hypertension.Results:Both drugs can significantly lower blood pressure(PPConclusions:Amlodipine besylate and valsartan are both relatively safe and effective long-acting antihypertensive drugs.Amlodipine besylate is better than valsartan on the controlling of morning systolic blood pressure.There is no difference on morning diastolic blood pressure.