Abstract: Objective: To compare the analgesic effects of propofol and nitric oxide on painless artificial abortion.Methods: Two hundred women with early pregnancy were randomly divided into two groups.Propofol combined with a little fentanyl was used in the observation group while 50% nitric oxide combined with 50% oxygen was used in the control group.The effects of analgesia,cervix relaxation,the occurrence of artificial abortion syndrome and bleeding during the operation were observed.Results: Both propofol and nitric oxide had good effect of analgesia and cervix relaxation.Propofol had a better effect than nitric oxide in artificial abortion(P<0.05).There was no significant difference in the occurrence of artificial abortion syndrome and the quantity of bleeding between the two groups(P>0.05).The time of the mobilization of the patients in the observation group is significantly later than that in the control group(P<0.001).Conclusions: Both propofol and nitric oxide have a good effect of analgesia in the induced abortion.Propofol is better than nitric oxide.