食管癌放疗过程中靶中心移位299例临床分析

    Target center bias in radiotherapy for patients with esophageal carcinoma: A report of 299 cases

    • 摘要: 目的: 探讨影响食管癌放疗过程中靶中心移位的相关因素。方法: 对299例食管癌患者于肿瘤剂量达40Gy时在模拟定位机下用游标卡尺测量出新的照射野中心点(新靶中心)与原照射野中心点(原靶中心)之间在X轴(左右方向)和Y轴(上下方向)上的偏移距离。结果: 299例患者靶中心左右移位发生率为80.6%,上下移位发生率为66.9%。移位与病变部位、病变长度、软组织肿块影、X线大体类型均有明显关系(P<0.01~P<0.005),不同病理类型与靶中心移位均无明显关系(P>0.05)。结论: 食管癌的病变部位、病变长度、X线大体类型、软组织肿块影可能是影响靶中心偏移的相关因素。

       

      Abstract: Objective: This study was designed to characterize the ultrastructure of the coccoid Helicobacter pylori(H. pylori) forms in the tissues of carcinoma.Methods: Transmission electron microscopy(TEM) technique was used to examine the structure of coccoid H. pylori in 4 cases of gastric carcinoma and 2 cases of esophageal carcinoma.Results: It was found that the coccoid H. pylori were scattered in cancer nest and cancer interspace,some of which enterded cancer cells,macrophages and other cells.The coccoid H. pylori appeared to be similar to the L-forms of other bacteria with varying cell shape and size,different cytoplasmic electron densities and defects in cell wall.Two types of coccoid H. pylori could be distinguished in the tissues of carcinoma by TEM.Type A was smaller with higher electron density in the cytoplasma,and flagellation on the cell membrane,suggesting that it could be viable.However,the type B was larger with lower electron density in the cytoplasma,and no flagellation on the cell membrane,suggesting that it could be a degenerative form.Conclusions: The coccoid forms of H.pulori still have certain degree of viability,thus they may play an important role in the transmission of H. pylori,the relapse of H. pylori related disease after treatment and the development of the related carcinoma.

       

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