Abstract: Objective: To explore and practice the biochemistry inquiry teaching according to the “excellent doctor” training program.Methods: The biochemistry inquiry teaching was carried out in “excellent doctor education reform experimental class” of clinical medicine specialty of Bengbu Medical College,the teaching effect was compared with the traditional teaching method.Results: The ability of independent learning,consciousness of innovation,critical thinking,spirit of teamwork,ability of language expression,communication and ability of reading literature in experimental class were significantly better than those in control class(P<0.01).Conclusions: The effects of inquiry teaching on the abilitiy of solving problem and innovation are better than whose of traditional teaching,which is beneficial to the development of the “excellent doctor”.