Abstract: Objective: To evaluate the effect of ileus tube,parenteral nutrition and octreotide combined in treatment of patients with intestinal obstruction.Methods: Sixty-four patients were randomly divided into three groups:group A were treated with ileus tube,group B with ileus tube and parenteral nutrition and group C with ileus tube,parenteral nutrition and octreotide.The therapy lasted for 7 to 14 days.Results: The ileus removing rates were 85.0%(A),85.7%(B) and 91.3%(C) respectively,in the three groups(P>0.05).On the 15th day,the serum pro albumin was(217.51±56.32)g/ml(A),(301.32±72.58)g/ml(B) and (328.39±64.19)g/ml(C)(P<0.01).The serum essential fatty acid was(31.98±19.91)μmol/L(A),(66.72±20.54)μmol/L(B) and (58.88±24.63)μmol/L(C)(P<0.01).In C group,the ceasing time of the abdomen pain was (50.28±24.37)hours,the time of the fecal passage was (65.49±37.30)hours,the disappearing time of the stepladder distribution of distended small-bowel loops in the radiologic film was (77.24±38.10)hours(P<0.01),the volume of stomach and intestinal suction was lower than that in other groups.Conclusions: The results show that application of ileus tube combined with parenteral nutrition and somatostatin can improve the nutritious condition of the patients and increase the cure rate.