Abstract: Objective:To explore the drug resistance and clinical distribution of Bauman acinetobacter,and provide a basis for controlling hospital infection. Methods:The clinical distribution,drug resistance and sample separation of 129 strains of Bauman acinetobacter were analysed,and the resistance rate of 14 kinds of commonly used antimicrobial agents were calculated. Results:Sputum specimens detection rate with 72.09% was highest,patients came mainly from physicians and intensive care treatment ward.The drug resistance rates of only 3 types of antimicrobial agents in 129 stains Bauman acinetobacter were less than 30%,imipenem,piperacillin/tazobactam and ampicillin/Shu TAZ were 24.80%,26.35% and 27.90%,respectively,the others drug resistance rates were more than 50%. Conclusions:As to the serious multi-drug resistance of Bauman acinetobacters,the resistance monitoring should be strengthened for directing clinical medication.