刘国强, 李志军. 未分化结缔组织病92例临床分析[J]. 蚌埠医学院学报, 2012, 36(3): 264-266.
    引用本文: 刘国强, 李志军. 未分化结缔组织病92例临床分析[J]. 蚌埠医学院学报, 2012, 36(3): 264-266.
    LIU Guo-qiang, LI Zhi-jun. Clinical analysis of 92 cases of undifferentiated connective tissue diseases[J]. Journal of Bengbu Medical College, 2012, 36(3): 264-266.
    Citation: LIU Guo-qiang, LI Zhi-jun. Clinical analysis of 92 cases of undifferentiated connective tissue diseases[J]. Journal of Bengbu Medical College, 2012, 36(3): 264-266.

    未分化结缔组织病92例临床分析

    Clinical analysis of 92 cases of undifferentiated connective tissue diseases

    • 摘要: 目的:探讨未分化结缔组织病(undifferentiated connective tissue diseases,UCTD)的临床特征和血清学变化特点,提高对UCTD的认识。方法:分析92例UCTD患者的临床表现、实验室检查及治疗情况等。结果:最常见的临床表现为关节病变67例,发热30例,雷诺现象25例,白细胞计数下降13例,肺间质病变8例,口干和(或)眼干7例。血清学抗核抗体阳性率100%,其中抗u1RNP抗体阳性29例,抗SSA/RO60阳性21例,抗SSA/RO52阳性16例,免疫球蛋白升高23例,补体C3降低17例。结论:UCTD的临床和血清学特征呈现为一种温和的简化的结缔组织病表现,除伴有肺间质病变外,一般症状较轻,预后较好。患者转归情况有待进一步随访观察。

       

      Abstract: Objective:To explore the clinical features and serological characteristics of patients with undifferentiated connective tissue diseases(UCTD) so as to elevate the cognition of UCTD.Methods:The clinical features,laboratory data and management of 92 patients with UCTD were analyzed retrospectively.Results:The most common clinical manifestations were the joint disease(67 cases),fever(30 cases),Raynauds phenomenon(25 cases),decreased white blood cell count(13 cases),interstitial lung disease(8 cases),and dry mouth and/or dry eye(7 cases).The positive rate of serum anti-nuclear antibody reached 100%,among which anti u1RNP antibodies accounted for 29 cases,anti-SSA/RO60 21 cases,anti-SSA/RO52 16 cases,elevated immunoglobulin 23 cases and decreased complement C3 17 cases.Conclusions:The clinical and serological manifestations of UCTD are moderate simplified connective tissue diseases.Excepting for the interstitial lung disease,the symptoms of other diseases are generally mild and the prognosis is good.The conversion of the patients needs further follow-up.

       

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