Significance and expressions of HIF-1 and Bmi-1 in diffuse large B cell lymphoma
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摘要: 目的：研究缺氧诱导因子1(HIF-1)和B细胞特异单克隆白血病毒整合位点1(Bmi-1)在弥漫大B细胞淋巴瘤(DLBCL)中的表达及相关性，探讨二者在DLBCL发生发展中的作用及临床意义。方法：免疫组织化学法检测64例DLBCL石蜡标本和40例淋巴结反应性增生(RH)组织中HIF-1和Bmi-1的表达，并分析两者的相关性及其与DLBCL临床特征之间的关系。结果：HIF-1和Bmi-1在DLBCL组织中的阳性率分别为67.19%和64.06%，与对照组差异均有统计学意义(P；0.01)。HIF-1和Bmi-1的表达在临床分期及非霍奇金淋巴瘤国际预后指数间差异均有统计学意义(P；0.01)，在年龄、性别、淋巴结外侵犯、全身症状间差异均无统计学意义(P；0.05)。结论：HIF-1和Bmi-1在DLBCL的发生发展中具有协同作用，可作为DLBCL的疗效和预后指标。
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关键词:
- 淋巴瘤,非霍奇金 /
- 缺氧诱导因子1 /
- B细胞特异单克隆白血病毒整合位点1
Abstract: Objective:To study the expressions and relationships of hypoxia-inducible factor-1(HIF-1) and B-cell-specific moloney leukemia virus insert site 1(Bmi-1)in diffuse large B cell lymphoma(DLBCL) tissue,and explore their roles and significance in the progression of carcinogenesis.Methods:The expressions of HIF-1 and Bmi-1 in 64 paraffin wax samples of DLBCL and 40 lymph node reactive hyperplasia tissue samples were detected by immunohistochemistry.The relationships and clinical features of HIF-1 and Bmi-1 in DLBCL were analyzed.Results:The postive expression rates of HIF-1 and Bmi-1 in DLBCL were 67.19% and 64.06% respectively,there were significantly statitical differences(P0.01)compared with the control.The significantly different expressions of HIF-1 and Bmi-1 were related with clinical stage and IPI(international prognostic index)(P0.01),and there were no obvious correlation with sex,age,out of lymph nodenode invasion and systemic symptoms of patient(P0.05).Conclusions:HIF-1 and Bmi-1 play a synergistic role in the progression of DLBCL,and can be used as an efficacious and prognostic reference indication of DLBCL. -
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