宋红梅, 吴延海, 骆祥芬, 吴维. 阿立哌唑对难治性抑郁症的增效作用观察[J]. 蚌埠医学院学报, 2012, 36(3): 286-287.
    引用本文: 宋红梅, 吴延海, 骆祥芬, 吴维. 阿立哌唑对难治性抑郁症的增效作用观察[J]. 蚌埠医学院学报, 2012, 36(3): 286-287.
    SONG Hong-mei, WU Yan-hai, LUO Xiang-fen, WU Wei. Synergistic effect of aripiprazole on the treatment of treatment-resistant depression[J]. Journal of Bengbu Medical College, 2012, 36(3): 286-287.
    Citation: SONG Hong-mei, WU Yan-hai, LUO Xiang-fen, WU Wei. Synergistic effect of aripiprazole on the treatment of treatment-resistant depression[J]. Journal of Bengbu Medical College, 2012, 36(3): 286-287.

    阿立哌唑对难治性抑郁症的增效作用观察

    Synergistic effect of aripiprazole on the treatment of treatment-resistant depression

    • 摘要: 目的:探讨小剂量阿立哌唑联合米氮平治疗难治性抑郁症的疗效和安全性。方法:将46例难治性抑郁症患者随机分为单用组23例,单用米氨平15~45 mg/d;合用组23例,同时服用阿立哌唑10~20 mg/d,疗程均6周。采用汉密尔顿抑郁量表和治疗中出现的症状量表于治疗前及治疗1、2、4、6周评定疗效及不良反应。结果:合用组治疗第4周,疗效优于单用组(P;0.05)。2组不良反应多较轻微。结论:米氮平合用小剂量阿立哌唑治疗难治性抑郁症可提高疗效,安全性好。

       

      Abstract: Objective:To explore the efficacy and safety of small-dose aripiprazole combined with mirtazapine in the treatment of treatment-resistant depression.Methods:Forty-six patients with treatment-resistant depression were randomly divided into combined group(treated with aripiprazole plus mirtazapine)and single group(treated with mirtazapine alone),23 cases in each group,period of treatment was 6 weeks.Hamilton depression scale and treatment emergent symptom scale were used to evaluate the clinical efficacy and adverse effects before treatment and at the end of 1st,2nd,4th and 6th week treatment.Results:The therapeutic efficacy of aripiprazole combined with mirtazapine was significantly better than that of mirtazapine group after 4 weeks treatment(P0.05).There was no significant difference in adverse events between the two groups.Conclusions:Small-dose aripiprazole combined with mirtazapine can augment the efficacy in the treatment of treatment-resistant depression and has a better safety.

       

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