Synergistic effect of aripiprazole on the treatment of treatment-resistant depression
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摘要: 目的：探讨小剂量阿立哌唑联合米氮平治疗难治性抑郁症的疗效和安全性。方法：将46例难治性抑郁症患者随机分为单用组23例，单用米氨平15～45 mg/d；合用组23例，同时服用阿立哌唑10～20 mg/d，疗程均6周。采用汉密尔顿抑郁量表和治疗中出现的症状量表于治疗前及治疗1、2、4、6周评定疗效及不良反应。结果：合用组治疗第4周，疗效优于单用组(P；0.05)。2组不良反应多较轻微。结论：米氮平合用小剂量阿立哌唑治疗难治性抑郁症可提高疗效，安全性好。Abstract: Objective:To explore the efficacy and safety of small-dose aripiprazole combined with mirtazapine in the treatment of treatment-resistant depression.Methods:Forty-six patients with treatment-resistant depression were randomly divided into combined group(treated with aripiprazole plus mirtazapine)and single group(treated with mirtazapine alone),23 cases in each group,period of treatment was 6 weeks.Hamilton depression scale and treatment emergent symptom scale were used to evaluate the clinical efficacy and adverse effects before treatment and at the end of 1st,2nd,4th and 6th week treatment.Results:The therapeutic efficacy of aripiprazole combined with mirtazapine was significantly better than that of mirtazapine group after 4 weeks treatment(P0.05).There was no significant difference in adverse events between the two groups.Conclusions:Small-dose aripiprazole combined with mirtazapine can augment the efficacy in the treatment of treatment-resistant depression and has a better safety.
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Keywords:
- depression /
- aripiprazole /
- mirtazapine
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