Abstract: Objective:To explore the method and clinical effect of trabeculectomy for acute angle-closure glaucoma(ACG) with continuous high intraocular pressure(IOP).Methods:Fifty-six patients(56 eyes) were accepted trabeculectomy whose IOP were continuously over 40 mmHg after use of repressive pressure medicine more than 3 days,including dropping IOP before surgery,releasing aqueous humor slowly and repetitiously,using releasable suture and injecting blind source separation to renew the anterior chamber depth.Results:There were no serious complications such as suprachoroidal space bleeding and malignant glaucoma.The vision was between 0.01-0.1 in 16 eyes,0.1-0.8 in 40 eyes.Most of the cases had better vision than before(P0.01).The post-operative IOP was 21 mmHg in 48 eyes,which was significantly lower than before surgery(P0.01).Choroidal detachment was occurred in 3 eyes,delayed anterior chamber reformation for strong filteration in 2 eyes,and high IOP for low filteration in 2 eyes.Conclusions:It is necessary and safety to do trabeculectomy for ACG with continuous high state of IOP.