Abstract: Objective:To study the clinical significance of serum high-sensitivity C reactive protein(hs-CRP) measurement,and explore the relationships between hs-CRP and immunoglobulin(IgG,IgA and IgM),complement(C3 and C4)in maintenance hemodialysis(MHD) patients.Methods:The level of serum hs-CRP was detected in 93 MHD patients and 40 healthy controls by an automated latex-enhanced immune transmission turbidity method.At the same time,the levels of IgG,IgA,IgM and C3,C4 were determined.According to the normal value(0-10mg/L) of hs-CRP,93 patients were divided into 2 groups:the normal hs-CRP group(63 patients) and the abnormal hs-CRP group(30 patients),and the changes of serum immunoglobulin and complement among the 3 groups were analyzed.Results:The level of hs-CRP in MHD patients was significantly higher than that in healthy controls(P0.01),but C3 was remarkably lower than that in healthy controls(P0.01).IgG in the abnormal hs-CRP group of MHD patients was significantly higher than that in the normal hs-CRP group(P0.01).Conclusions:The increasing of hs-CRP and IgG levels is beneficial to judge the chronic infection of MHD patients,and the decrease of C3 level is the important reason for the decline of humoral immunity in MHD patients.