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    王子安, 陶言言, 赵富友, 毕国斌. 原癌基因Fra-1在胃癌组织中的表达及临床意义[J]. 蚌埠医科大学学报, 2013, 37(1): 24-27.
    引用本文: 王子安, 陶言言, 赵富友, 毕国斌. 原癌基因Fra-1在胃癌组织中的表达及临床意义[J]. 蚌埠医科大学学报, 2013, 37(1): 24-27.
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    WANG Zi-an, TAO Yan-yan, ZHAO Fu-you, BI Guo-bin. Expression of Fra-1 and its clinical significance in gastric carcinoma tissues[J]. Journal of Bengbu Medical University, 2013, 37(1): 24-27.
    Citation: WANG Zi-an, TAO Yan-yan, ZHAO Fu-you, BI Guo-bin. Expression of Fra-1 and its clinical significance in gastric carcinoma tissues[J]. Journal of Bengbu Medical University, 2013, 37(1): 24-27.
    shu

    原癌基因Fra-1在胃癌组织中的表达及临床意义

    Expression of Fra-1 and its clinical significance in gastric carcinoma tissues

      摘要
    • 摘要: 目的：探讨胃癌组织中Fra-1 mRNA的表达及临床意义。方法：收集50例胃癌标本及相关临床病理资料，以RT-PCR方法检测胃癌组织、癌旁正常组织中Fra-1 mRNA的表达情况。结果：Fra-1 mRNA在胃癌组织中的表达高于癌旁正常组织(P0．01)，而其表达在胃癌的淋巴结转移、浸润深度、TNM分期间差异均有统计学意义(P0．05)，而在患者的性别、年龄、肿瘤分化程度和大小间差异均无统计学意义(P0．05)。结论：Fra-1的高表达可能与胃癌的发生及侵袭转移有关，可能成为胃癌早期诊断的分子指标及分子靶向治疗的新靶点。

       

      Abstract: Objective:To investigate the clinical significance of Fra-1 expression in gastric carcinoma tissues. Methods:The clinical and pathological data of 50 cases of gastric carcinoma were collected. The expression of Fra-1 in the gastric carcinoma tissues and the paraneoplastic tissues were detected using RT-PCR. Results:The expression of Fra-1 in gastric carcinoma tissues was higher than that in paraneoplastic tissues(P0. 01). The expression of Fra-1 was related to the lymph node metastasis, depth of invasion and TNM stages (P 0. 05),but not related to the gender, age, cancer differentiation or size of the tumour(P0. 05). Conclusions:High expression of Fra-1 may be related to the genesis and progression of gastric carcinoma, it may act as a molecule parameter in the early diagnosis of gastric carcinoma and a potential target in the targeted therapy.

       

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