Abstract: Objective: To evaluate the effects of calcium-magnesium ( Ca/Mg) infusion and mecobalamin on preventing the neurotoxicity induced by oxaliplatin. Methods:Taking the method of random and placebo control,90 patients with colon cancer treated with oxaliplatin + fluorouracil + calcium folinate chemotherapy were randomly divided into three groups which were treated with Ca/Mg infusion, mecobalamin and normal saline, respectively. According to Sanofisyn thelabo and neuropathy symptom score (NSS),the neurotoxicity incidence and severity of all patients were observed. Results:The actue neurotoxicity incidence of normal saline,Ca/Mg infusion and mecobalamin group were 27 cases(93. 1%),20 cases(66.7%) and 19 cases(65. 5%),respectively,which differences were statistical significance(P0.05). There were significant difference between the chronic neurotoxicity of three groups after 3 cycles of chemotherapy(P0. 01). TheⅠ-Ⅲ degree neurotoxicity of Ca/Mg infusion and mecobalamin groups were no difference(P 0.05),but which were lower than that of chemotherapy group(P0.01 to P0.05). After 6 cycles of chemotherapy,there were significant differences between the incidence of neurotoxicity of three groups(P0.05),the neurotoxicity of Ca/Mg infusion group was lower than that of chemotherapy group(P0.05),and the differences of mecobalamin and chemotherapy groups were not statistical significance(P0.05). The NSS score of chemotherapy group was higher than that of other two groups after 3 and 6 cycles of chemotherapy(P0.01 and P0.05),but for other two groups had no differences(P0.05). Conclusions:Ca/Mg infusion and mecobalamin can decrease the incidence and intensity of neurotoxicity induced by oxaliplatin.