Abstract: Objective:To observe the effects of preemptive analgesia with parecoxib on patient-controlled intravenous analgesia (PCIA) after lumbar operation. Methods:Eighty cases(ASA Ⅰ-Ⅱ) with lumbar operation were randomly divided into parecoxib group(group P) and control group(group C). Parecoxib sodium 40 mg was injected into the patients in group P before 10 min of anesthesia induction, patients in group C were not injected any drugs. All patients were used PCIA by pentazocine combined with sufentanil after surgery. Visual analogous scale(VAS) and bruggman comfort scale(BCS) scores of all patients were recorded at 6,12,24,36 and 48 hours after surgery. Total times of the PCIA press and times of effective press within 48 hours, and the cumulative doses of sufentanil consumption and the adverse reactions were also recorded. Results:The VAS scores of group P were significantly lower than that of group C,but the BCS scores were significantly higher compared with group C(P0. 01). Total times of the PCIA press and times of effective press of group P were significantly less than those of group C(P0. 01) within 48 hours,and the cumulative doses of sufentanil consumption and the adverse reactions were also less compared with group C(P0. 05). Conclusions:Parecoxib sodium 40mg injecting 10 min before anesthesia induction can improve the analgesic effects of pentazocine combined with sufentanil on PCIA after lumbar operation, and reduce the cumulative doses of sufentanil consumption and the adverse reactions.