张文学, 王莉, 于莉, 马勇. 硫普罗宁治疗酒精性肝病的临床疗效观察[J]. 蚌埠医学院学报, 2013, 37(1): 51-53.
    引用本文: 张文学, 王莉, 于莉, 马勇. 硫普罗宁治疗酒精性肝病的临床疗效观察[J]. 蚌埠医学院学报, 2013, 37(1): 51-53.
    ZHANG Wen-xue, WANG Li, YU Li, MA Yong. Treatment of Alcoholic Liver Disease with Tiopronin[J]. Journal of Bengbu Medical College, 2013, 37(1): 51-53.
    Citation: ZHANG Wen-xue, WANG Li, YU Li, MA Yong. Treatment of Alcoholic Liver Disease with Tiopronin[J]. Journal of Bengbu Medical College, 2013, 37(1): 51-53.

    硫普罗宁治疗酒精性肝病的临床疗效观察

    Treatment of Alcoholic Liver Disease with Tiopronin

    • 摘要: 目的:观察硫普罗宁治疗酒精性肝病(ALD)的疗效。方法:将61例ALD患者分为2组,其中对照组30例给予门冬氨酸钾镁、复方丹参治疗,治疗组31例在对照组治疗方案基础上加用硫普罗宁0.2 g,每天一次,2组均治疗1个月;观察治疗前后肝功能指标的变化,同时观察药物不良反应。结果:2组治疗后天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、-谷氨酰转肽酶(-GT)均低于治疗前(P0.01),且治疗后治疗组AST和ALT下降程度均明显高于对照组(P0.01);治疗后治疗组肝功能AST和ALT复常率均高于对照组(P0.05);在治疗组中,1例在治疗后肝组织中重度肝脂肪变性和散在的炎症细胞浸润明显减轻,假小叶消失。结论:硫普罗宁在治疗ALD中不良反应少,患者依从性好,是治疗ALD安全、有效的药物。

       

      Abstract: Objective:To observe the therapeutic effect of Tiopronin on alcoholic liver diseases. Methods:Sixty-one cases with alcoholic liver diseases were divided into two groups. The control group received Potassium Magnesium Aspartate and Fu Fang Dan Shen, while the treatment group were administered Tiopronin in addition to the therapy the control group received. The treatment lasted for one month. The serum AST,ALT,TBIL and -GT of the two groups were detected before and after the therapy and the side effects were observed. Results:After therapy, the levels of AST,ALT,TBIL and -GT in both groups were decreased(P0. 01),and the levels of AST and ALT in the treatment group were lower than those in the control group(P0. 01). The normalization rates of AST and ALT in the treatment group were higher than those in the control group(P0. 05). The severe steatosis and evident inflammation of one case in the treatment group improved significantly, and the pseadolobuli in the hepatic tissue disappeared after the therapy. Conclusions: Tiopronin is an effective drug for the treatment of patients with alcoholic liver diseases.

       

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