Abstract: Objective:To explore the effect of sequential administration of mifepristone and misoprostol in terminating early pregnancy in women with uterine scars. Methods:Eighty-two cases of early pregnancy that had uterine scars and required termination of pregnancy were divided into two groups. Fifty-six cases in control group were performed painless artificial abortion;26 cases in observation group were administered mifepristone and misoprostol in sequence. The analgesic effect, cervical dilation, blood loss, dosage of propofol, postoperative vaginal bleeding time, operation time, residual cavity and uterine perforation were compared between the two groups. Results:The analgesic effect of both groups was 100%;The cervical dilation in the observation group reached 100%. The usage amount of propofol, operation time and postoperative vaginal bleeding in the observation group was less than those in the control group(P0. 01). There was no significant difference between the two groups in the intraoperative blood loss, rate of post-operative abdominal pain and rate of uterine residual(P 0. 05). No uterine perforation occurred in the two groups. Conclusions:Mifepristone combined with misoprostol is safe and effective in terminating early pregnancy in women with cicatricial uterus, as it can effectively reduce the uterine damage, bleeding volume and abortion complications.